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to examine the association between trait and defensive network connectivity and the modulatory effect of oxytocin on it
Individuals with high trait anxiety show stable anxiety proneness even in the absence of real threat, which could be a result of intrinsic hyper-connectivity in the defensive systems. In the present study, healthy subjects' trait anxiety levels will be assessed by the sub-trait inventory of the State-Trait Anxiety Inventory. Then two experiments using resting-state fMRI technique will be conducted to first map how hubs in the defensive systems organized in high anxious individuals in a stimuli-free situation (Experiment 1) and then we will examine the modulatory effect of the intranasal administration of oxytocin on functional connectivity in these independently defined defensive networks (Experiment 2).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high trait anxiety group | Experimental | experiment 1: identified according to scores of the trait anxiety scale. |
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| low trait anxiety group | Experimental | experiment 1: identified according to scores of the trait anxiety scale. |
|
| oxytocin group | Experimental | experiment 2: intranasal administration of oxytocin |
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| placebo control group | Placebo Comparator | experiment 2: intranasal administration of placebo |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| trait anxiety scale | Behavioral | splitting subjects into 2 groups according to scores of the trait anxiety scale |
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| Measure | Description | Time Frame |
|---|---|---|
| the resting state functional connectivity changes in the defensive network | The resting-state activity can be accessed using functional magnetic resonance imaging (fMRI) by measuring spontaneous and low-frequency fluctuations (< 0.1 Hz) when the brain is at rest. Group differences will be calculated in the high trait anxiety group relative to the low trait anxiety group and in the oxytocin group relative to the placebo group. | one day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Keith Kendrick, Dr. | University of Electronic Science and Technology of China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| school of life science and technology, University of Electronic Science and Technology of China | Chengdu | Sichuan | 610054 | China |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Oxytocin | Drug | intranasal administration of oxytocin |
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| Placebo | Drug | intranasal administration of placebo |
|
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |