Association between serum anti-Mullerian hormone (AMH) level and prevalence of glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS)

• To study the association between serum anti-Mullerian hormone (AMH) level and glucose intolerance and metabolic syndrome in women with polycystic ovary syndrome (PCOS).

• Glucose intolerance is detected by 2-hours 75 gram oral glucose tolerance test (OGTT).

• Metabolic syndrome is diagnosed by using the Harmonized criteria; the presence of any 3 of 5 following risk factors constitutes a diagnosis of metabolic syndrome.

  1. Elevated waist circumference (> 80 cm in Asian women)
  2. Elevated triglycerides (> 150 mg/dL)
  3. Reduced HDL-cholesterol (< 50 mg/dL)
  4. Elevated blood pressure )systolic > 130 and/or diastolic > 85 mmHg)
  5. Elevated fasting glucose ( > 100 mg/dL)

• Percentage of glucose intolerance and metabolic syndrome in PCOS women as well was any differences in parameters between PCOS patients with and without glucose intolerance and metabolic syndrome will be analysed.

Inclusion Criteria:

• PCOS diagnosed by Rotterdam criteria 2003

Exclusion Criteria:

• Pregnancy
• Previous any hormonal uses in the last 3 months
• Previous hypoglycemic drugs or insulin-sensitising agents use in the last 3 months
• Previous chemotherapy, ovarian surgery, pelvic irradiation
• Menopause

Thai women with PCOS diagnosed by Rotterdam criteria 2003 who visit at Gynecological Department, King Chulalongkorn Memorial Hospital, Bangkok,Thailand