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Cardiac arrhythmias are a well-recognized complication of anesthesia for laparoscopy. The aim of this study was to evaluate the efficacy of atropine sulfate for prevention of brad arrhythmia induced by repeated succinylcholine during gynecological laparoscopic surgery.
120 candidates, ASA 1 in the age range 18-40 years scheduled for elective diagnostic gynecological laparoscopic surgery were randomly assigned into 4 groups to receive either atropine sulfate or normal saline solution (as placebo).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Active Comparator | Intramuscular (IM) atropine (0.01 mg/kg) (1 ml) 30 minutes before induction of anesthesia, IV normal saline 10 ml 3 minutes before induction of anesthesia and normal saline mixed with second dose succinylcholine (1mg/kg) in 5 ml syringe with normal saline |
|
| Group B | Active Comparator | 1 ml normal saline IM 30 minutes before induction of anesthesia, intravenously (IV) atropine (0.01 mg/kg) in 10 ml 3 minutes before induction of anesthesia and normal saline mixed with second dose succinylcholine (1mg/kg) in 5 ml syringe with normal saline |
|
| Group C | Active Comparator | IM normal saline 1 ml normal 30 minutes before induction of anesthesia, IV normal saline 10 ml 3 minutes before induction of anesthesia and 1mg/kg atropine mixed with second dose succinylcholine (1mg/kg) in 5 ml syringe with normal saline |
|
| Group D | Placebo Comparator | IM normal saline 1 ml normal 30 minutes before induction of anesthesia, IV normal saline 10 ml 3 minutes before induction of anesthesia and normal saline mixed with second dose succinylcholine (1mg/kg) in 5 ml syringe with normal saline |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IM atropine | Drug | Atropine (0.01 mg/kg) (1 ml) IM 30 minutes before induction of anesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of bradycardia | heart rate less than 60 per minutes or decrease more than 30% of baseline reading | within the first 2 hours during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Nasopharyngeal secretion | suction of Nasopharyngeal secretion (ml) during and after extubation | within the first 4 hours during surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| sayed abd elshafy, M | associate professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine | Asyut | Asyut Governorate | Egypt |
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|
| IV atropine | Drug | Atropine (0.01 mg/kg) intravenously (10 ml) 3 minutes before induction of anesthesia |
|
|
| Atropine mixed with second dose succinylcholine | Drug | Atropine (0.01 mg/kg) added to the second dose succinylcholine (1mg/kg) prepared to 5 ml syringe with normal saline |
|
|
| IM normal saline | Drug | 1 ml normal saline IM 30 minutes before induction of anesthesia |
|
|
| IV normal saline | Drug | IV 10 ml normal saline 3 minutes before induction of anesthesia |
|
|
| Normal saline mixed with second dose succinylcholine | Drug | Second dose succinylcholine (1 mg/kg) prepared to 5 ml syringe with normal saline |
|
|
| ID | Term |
|---|---|
| D001919 | Bradycardia |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001285 | Atropine |
| D013390 | Succinylcholine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D001286 | Atropine Derivatives |
| D014326 | Tropanes |
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D009930 | Organic Chemicals |
| D001533 | Belladonna Alkaloids |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D002794 | Choline |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D013386 | Succinates |
| D003998 | Dicarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009861 | Onium Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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