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IRB approval expired
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We will investigate whether measurement of the change in thickness of the diaphragm during the respiratory cycle by ultrasound can predict extubation success in a 48 hour window. We will also asses whether this is only possible on low levels of pressure support as has been shown previously, or if this technique retains its predictive power at higher levels of pressure support.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Main Cohort | all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diaphragm Ultrasound | Procedure | Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5 |
| Measure | Description | Time Frame |
|---|---|---|
| Extubation Success | Discontinuation from mechanical ventilation in 48 hours from ultrasound PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Re-intubation | Reinstitution of mechanical ventilation within 48 hours of extubation PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | 48 hours from removal of ventilatory support |
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Inclusion Criteria:
Exclusion Criteria:
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Patients on mechanical ventilation in the intensive care unit
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| Name | Affiliation | Role |
|---|---|---|
| Scott Blumhof, DO | Einstein Healthcare Network | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | United States |
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0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
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| ID | Title | Description |
|---|---|---|
| FG000 | Main Cohort | all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound Diaphragm Ultrasound: Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5 0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
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| ID | Title | Description |
|---|---|---|
| BG000 | Main Cohort | all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound Diaphragm Ultrasound: Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5 PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Extubation Success | Discontinuation from mechanical ventilation in 48 hours from ultrasound PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | Posted | 48 hours |
|
0 participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
0 participant analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Main Cohort | all patients enrolled will have an ultrasound of their diaphragm performed once they are on a pressure support trial. Intervention: Diaphragm Ultrasound Diaphragm Ultrasound: Once on a pressure support weaning trial, enrolled subjects will have an ultrasound of their right hemidiaphragm performed on three levels of pressure support: 15/5 10/5 and 5/5 PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. |
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0 Participants analyzed. PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Roberta Costello; Research Compliance | Albert Einstein Healthcare Network | 215-456-7225 | bcostell@einstein.edu |
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| Age, Continuous | PI has left the institution. Efforts mad |
| Sex: Female, Male |
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| Region of Enrollment | participants |
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| Units | Counts |
|---|---|
| Participants |
|
| Secondary | Re-intubation | Reinstitution of mechanical ventilation within 48 hours of extubation PI has left the institution. Efforts made to contact the PI were unsuccessful. No study data available. | Not Posted | 48 hours from removal of ventilatory support | Participants |
| 0 |
| 0 |
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