Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia in Subjects With Normal Glucose Level and Impaired Fasting Glucose

The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Inclusion Criteria:

1) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL)

Exclusion Criteria:

1. history of taking an insulin-injection or oral hypoglycemic agents
2. evidence of alcohol abuse or alcoholism
3. pregnancy or breast feeding
4. chronic gastrointestinal disorder
5. seriously abnormal liver or renal function
6. an occupation at risk of death when hypoglycemia occurs