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This study assesses the impact of diastolic heart failure on exercise capacity in women who have a previous coronary condition. All the participants will go through the same evaluation.
It is well established that systolic heart failure impacts exercise capacity and quality of life, diastolic heart failure however, is not well documented as a condition that reduces physical performance.
To confirm that patients have a diastolic disfunction an echocardiography will be performed, this will also yield the left ventricle ejection fraction to confirm the preserved ejection fraction heart failure diagnostics.
Exercise capacity will be assessed using the distance walked on the six-minute walking test, performed on a 30m corridor.
Pulmonary function will be assessed with spirometry and values of forced vital capacity and forced expired volume in one second will be recorded and compared to the age-predicted values.
Respiratory strength will be determined by maximal pressure achieved on a respiratory manometer.
Peripheral muscular strength will be assessed with a handheld dynamometer. Knee extension strength of the dominant leg will be recorded.
An echocardiography will be performed to assess systolic and diastolic function and ejection fraction.
Heart autonomic function will be evaluated using a heart rate monitor and a computer software to identify the sympathovagal balance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diastolic Heart Failure | Women with diastolic heart failure and previous coronary artery disease |
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| Measure | Description | Time Frame |
|---|---|---|
| Functional Capacity | Measured by the distance walked in the six-minute walking test in meters. | Up to 1 year after diagnosis |
| Inflammatory markers | Inflammatory markers evaluated using specific assays for blood analysis Interleukin (IL) 1 (pg/mL), IL-6 (pg/mL), IL 8 (pg/mL),Tumor Necrosis Factor alpha (pg/mL), Brain Natriuretic Peptide (BNP) (pg/mL), pro-BNP (pg/mL); Lab results will be analysed for each marker and values will be compared to laboratory reference data to identify values out of range. | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Inflammatory Markers | Inflammatory markers evaluated using specific assays for blood analysis for high sensitivity C reactive protein (mg/L), alpha-1-acid glycoprotein (mg/dL) and platelets (platelets/cubic millimeters), lactate (mg/dL), uric acid (mg/dL) | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Measure | Description | Time Frame |
|---|---|---|
| Heart autonomic function | Sympathovagal balance assessed by heart rate variability using a heart monitor | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Quality of life |
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Inclusion Criteria:
Exclusion Criteria:
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Women with coronary artery disease diagnosed through angiography and heart failure with preserved ejection fraction diagnosed via ecocardiography.
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Figueiredo Alves da Silva, PT | Federal University of São Paulo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Federal University of Sao Paulo | São Paulo | São Paulo | 04024002 | Brazil |
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| ID | Term |
|---|---|
| D054144 | Heart Failure, Diastolic |
| D003324 | Coronary Artery Disease |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003327 | Coronary Disease |
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Venous blood and plasma.
Quality of life assessed by the Minnesota questionnaire specific for heart failure
| Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Pulmonary function | Pulmonary function assessed by spirometry for obtaining values of forced expired volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Respiratory muscle strength | Respiratory muscle strength assessed by manometer for obtaining maximal inspiratory pressure and maximal expiratory pressure values in cmH2O. | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| Peripheral muscle strength | Peripheral muscle strength assessed by the quadriceps strength using a portable dynamometer in kilogram-force (kgf) | Up to 1 year after diagnosis on the same day as functional capacity assessment |
| D017202 |
| Myocardial Ischemia |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |