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The aim of the study was to describe the relationship between the intensity of a standardized tetanic stimulation and the associated reflex pupillary dilation in patients under ketamine sedation.
After an intravenous bolus of 1 mg/kg of ketamine, tetanic stimulations were performed every minute at increasing intensities of 10, 20, 30, 40 and 60 milliamps (similar to the stimulations of neuromuscular blocking agents monitoring). Pupillary diameter was measured before and after each stimulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ketamine sedation | Experimental | Procedure scheduled under ketamine sedation. Baseline pupillary diameter measurement in alert subjects. Injection of a bolus of 1 mg/kg of ketamine. Every minute, tetanic stimulations of incremental intensities (10-20-30-40-60 milliamps), during 5 seconds. Pupillary diameter measurement before and after each stimulation. End of study period, beginning of procedure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ketamine | Drug | bolus 1 mg/kg |
| |
| Tetanic stimulations of incremental intensities |
| Measure | Description | Time Frame |
|---|---|---|
| Pupillary dilation: difference between post- and pre-stimulation pupillary diameter assessed by videopupillometry | Non-invasive measurement of pupillary diameter using an infrared camera, for each of the 6 stimulations per patient | 30 seconds after each stimulation (6 stimulations per patient) |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate variation | 30 seconds after each stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Isabelle Constant, PHD | University Hospital Armand Trousseau | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement d'anesthesie Hopital Armand Trousseau | Paris | 75012 | France |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D007649 | Ketamine |
| ID | Term |
|---|---|
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
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| Procedure |
10-20-30-40-60 milliamps on the patient's left forearm |
|
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |