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Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal saline | Placebo Comparator |
| |
| Dex | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Administration of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with postoperative cognitive decline assessed by mini-mental state examination | to compare cognitive decline after surgery between control and dexmedetomidine group with mini-mental state examination. | from 1 day before surgery to postoperative 1 day |
| Number of patients with postoperative cognitive decline assessed by a battery of psychometric test | to compare cognitive decline after surgery between control and dexmedetomidine group with a battery of psychometric test. The battery consists of copy geometric form test, two-dimensional model test, grooved pegboard test, colored block design test, puzzle test, clock drawing test. | from 1 day before surgery to postoperative 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with increase of S100ß protein after surgery assessed by ELISA assay with blood of patients | S100ß protein is the biologic marker for neuroinflammation | from 5 min after induction of anesthesia to an 1 hour after surgery |
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Inclusion Criteria:
1. Patients undergoing shoulder arthroscopic surgery with beach chair position
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine | Seoul | 03722 | South Korea |
There is no plan to share the data.
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| normal saline |
| Drug |
Administration of same amount of dexmedetomidine at a rate 0.6 ug/kg/hr during surgery. |
|
| ID | Term |
|---|---|
| D000070636 | Rotator Cuff Injuries |
| ID | Term |
|---|---|
| D012421 | Rupture |
| D014947 | Wounds and Injuries |
| D000070599 | Shoulder Injuries |
| D013708 | Tendon Injuries |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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