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To evaluate changes in endothelial cell count after pterygium surgery with mitomycin C (MMC) 0.02%
To evaluate the change in endothelial cell count in patients after pterygium surgery with mitomycin C (MMC) 0.02% for 2 minutes in 2 groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pterygium surgery: Head and body. | Experimental | Application of Mitomycin C 0.02% after excision of the body and the head of the pterygium. |
|
| Pterygium surgery: Body. | Active Comparator | Application of Mitomycin C 0.02% after excision of the body only of the pterygium. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mitomycin C 0.02% | Drug | Pterygium excision with application of mitomycin C |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial cell count | 3 months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fani Segev, MD | Contact | +792526995044 | fsegev@netvision.net.il | |
| Leena Asalee, MD | Contact | +972543031396 | leenaasalee@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sackler school of medicine | Tel Aviv | Israel | Israel | |||
| Meir medical centre |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18520505 | Background | Avisar R, Avisar I, Bahar I, Weinberger D. Effect of mitomycin C in pterygium surgery on corneal endothelium. Cornea. 2008 Jun;27(5):559-61. doi: 10.1097/ICO.0b013e318165b158. | |
| 18992871 | Background | Bahar I, Kaiserman I, Lange AP, Slomovic A, Levinger E, Sansanayudh W, Slomovic AR. The effect of mitomycin C on corneal endothelium in pterygium surgery. Am J Ophthalmol. 2009 Mar;147(3):447-452.e1. doi: 10.1016/j.ajo.2008.08.035. Epub 2008 Nov 7. |
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| ID | Term |
|---|---|
| D011625 | Pterygium |
| ID | Term |
|---|---|
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
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| Pterygium surgery | Procedure | Two different procedures- excision of the head and the body and excision of the head only |
|
| Kfar Saba |
| Israel |
| 19654528 | Background | Avisar R, Apel I, Avisar I, Weinberger D. Endothelial cell loss during pterygium surgery: importance of timing of mitomycin C application. Cornea. 2009 Sep;28(8):879-81. doi: 10.1097/ICO.0b013e3181a3900c. |
| 21236405 | Background | Kheirkhah A, Izadi A, Kiarudi MY, Nazari R, Hashemian H, Behrouz MJ. Effects of mitomycin C on corneal endothelial cell counts in pterygium surgery: role of application location. Am J Ophthalmol. 2011 Mar;151(3):488-93. doi: 10.1016/j.ajo.2010.09.014. Epub 2011 Jan 13. |