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To evaluate the safety and efficacy of 5 seconds mitomycin-C (MMC) application during photorefractive keratectomy (PRK) for patients with low myopia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MMC group | Active Comparator | One eye of each patient was randomly assigned to receive intraoperative topical 0.02% MMC for 5 seconds. |
|
| BSS group | Placebo Comparator | One eye of each patient was randomly assigned to receive balanced salt solution (BSS) with the same manner. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mitomycin-C | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Central corneal endothelial cell density (ECD) 6 months after the PRK | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ophthalmic Research Center | Tehran | Tehran Province | 16666 | Iran |
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| ID | Term |
|---|---|
| D009216 | Myopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D016685 | Mitomycin |
| ID | Term |
|---|---|
| D008937 | Mitomycins |
| D045563 | Indolequinones |
| D011809 | Quinones |
| D009930 | Organic Chemicals |
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balanced salt solution (BSS) |
|
| D001389 |
| Azirines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |