Covid-2019

The PRE-AR project is a longitudinal observational study. The primary objective is the assessment of lung function parameters in late preterm preschool children.

The PRE-AR project is a longitudinal observational study. The primary objective is the assessment of lung function parameters in late preterm preschool children.

Pulmonary function tests will be performed.

Case group

Inclusion Criteria:

• Premature birth < 37 weeks
• 5 years old ≤ Age ≥ 3 years old

Control group

Inclusion Criteria:

• Full-term birth
• 5 years old ≤ Age ≥ 3 years old

Exclusion Criteria of both groups:

• Pulmonary bronchodysplasia (BDP)
• Acute respiratory infection
• Immunological and metabolic system disease
• Malformation of upper respiratory tract
• Topical or systemic therapies, with antibiotics, antihistaminics and corticosteroids, in the previous 30 days
• Patients with neurological pathologies
• Patients that are not able to perform the lung function tests

A study population of 59 prematurely born children (of both sex and 3-5 years old) attending as outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR).

A Control group of full-term born children (N=93), recruited by a collaborative Pediatricians network within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.

The subjects will be paired up according to the sex and to the age, with a ratio 1:1.

The IPD collected will be available on december 2023.

The following participant data will be shared:

• Pulmonary function tests
• Demographic characteristics

All IPD will be obtained from statistical analysis on the dedicated database in which all data are stored.