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| Name | Class |
|---|---|
| VA Eastern Colorado Health Care System | FED |
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Bone responds according to the load placed on it. In this study, investigators want to know if exercise that loads the body in exercises, like walking or jogging (Ground Reaction Forces: GRF), affects bone differently than exercises that load the joints, like weight lifting (Joint Reaction Forces: JRF). Participants will exercise at least 3 times a week for 6 months. Measures of bone strength and mass, muscular strength, and aerobic fitness will be taken at the beginning and the end of the 6 month program. Period blood samples will be taken for future analysis of blood markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ground Reaction Forces | Experimental | Participants will have an individualized exercise program that includes walking, jogging, stair climbing, and box jumping. |
|
| Joint Reaction Forces | Experimental | Participants will have an individualized exercise program that includes weight lifting and aerobic rowing. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ground Reaction Forces | Behavioral | 6 month exercise program that loads the body via gravitational forces. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Volumetric Bone Mineral Density (vBMD) | Measured via quantitative computed tomography (QCT) | Baseline and 6 month |
| Change in Areal Bone Mineral Density (aBMD) | Measured via dual-energy x-ray absorptiometry (DXA) | Baseline and 6 month |
| Change in Bone Strength | Measured via finite element analysis (FEA) from QCT | Baseline and 6 month |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 1-Repetition Maximum (1RM) | Baseline and 6 month | |
| Change in Maximal Oxygen Uptake (cardiovascular fitness) | Baseline and 6 month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wendy Kohrt, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | United States | ||
| Veteran's Affairs Eastern Colorado Healthcare System |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| Joint Reaction Forces | Behavioral | 6 month exercise program that loads the body via loading the joints. |
|
| Denver |
| Colorado |
| United States |
| D009750 |
| Nutritional and Metabolic Diseases |