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| Name | Class |
|---|---|
| University Hospitals, Leicester | OTHER |
| University Hospitals of Derby and Burton NHS Foundation Trust | OTHER |
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Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise leg | Experimental |
| |
| Control leg | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | multidirectional unilateral hopping exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in femoral neck bone mineral density | baseline, 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cortical bone mineral content | baseline, 12 months | |
| Change in trabecular bone mineral content | baseline, 12 months | |
| Change in ground reaction force during hopping |
| Measure | Description | Time Frame |
|---|---|---|
| Serum 25 hydroxy vitamin D | baseline | |
| Change in body fat content | baseline, 12 months | |
| change in energy intake (MJ/d) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Katherine Brooke-Wavell, PhD | Loughborough University | Principal Investigator |
| Winston Rennie, MBBS | University Hospitals Leicester NHS Trust | Principal Investigator |
| Jonathan Folland, PhD | Loughborough University | Principal Investigator |
| Greg Summers, MD | Derby University Hospitals Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loughborough University | Loughborough | Leicestershire | LE11 3TU | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23291565 | Result | Allison SJ, Folland JP, Rennie WJ, Summers GD, Brooke-Wavell K. High impact exercise increased femoral neck bone mineral density in older men: a randomised unilateral intervention. Bone. 2013 Apr;53(2):321-8. doi: 10.1016/j.bone.2012.12.045. Epub 2013 Jan 3. |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| baseline, 6 months, 12 months |
| Change in electromyography of quadriceps during hopping | baseline, 6 months |
| Change in postural sway amplitude (mm) | baseline, 6 months |
| Change in leg press strength | baseline, 6 months |
| Change in maximal isometric knee extensor strength | baseline, 6 months |
| Change in tendon stiffness | baseline, 6 months |
| baseline, 12 months |
| change in calcium intake | baseline, 12 months |