Validation of Structured Light Plethysmography - Health and Disease

Validation in Healthy Subjects and Different Diagnostic States

Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.

The investigators hypothesize that SLP may be a useful tool to differentiate between different respiratory diseases. To further examine differences in disease and health, and between diseases SLP measurements will be recorded in a range of diagnostic conditions that effect breathing and in healthy normal subjects.

This is a non-randomised observational study to validate Structured Light Plethysmography in two groups of participants: those with Respiratory condition such as COPD and a normal healthy group. Neither group will receive any clinical intervention. SLP data capture and spirometry (as part of the patients clinical care) will be performed by the patients. The data collected from this study will allow examination of different breathing patterns between patients with different diseases, to compare breathing patterns in patients to those in healthy individuals, and to compare breathing patterns within a healthy population.

Inclusion Criteria:

• Aged between 0 and 80 years

Exclusion Criteria:

• Any contraindication to spirometry (if performed) or a history of a myocardial infarction or chest surgery within 4 weeks
• Patient unable to sit in an upright (or supine in the case of infants) position for required period of time
• Patients with significant co morbidities (assessed by the clinician at screening only):
• Chest wall or spinal deformity e.g. scoliosis
• Obstructive Sleep Apnoea (OSA) Apnoea hypopnoea index > 30 (if known)
• An acute or chronic condition that, in the investigator's opinion, would limit the patient's ability to participate in the study
• BMI > 40
• Inability to consent/comply with trial protocol