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| Name | Class |
|---|---|
| Cambridge University Hospitals NHS Foundation Trust | OTHER |
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Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.
The investigators hypothesize that SLP may be a useful tool to differentiate between different respiratory diseases. To further examine differences in disease and health, and between diseases SLP measurements will be recorded in a range of diagnostic conditions that effect breathing and in healthy normal subjects.
This is a non-randomised observational study to validate Structured Light Plethysmography in two groups of participants: those with Respiratory condition such as COPD and a normal healthy group. Neither group will receive any clinical intervention. SLP data capture and spirometry (as part of the patients clinical care) will be performed by the patients. The data collected from this study will allow examination of different breathing patterns between patients with different diseases, to compare breathing patterns in patients to those in healthy individuals, and to compare breathing patterns within a healthy population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal | Participants with no diagnosis of respiratory disease between the ages of 0 and 80 | ||
| COPD | Patients from different diagnostic groups between the ages of 0 and 80 |
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| Measure | Description | Time Frame |
|---|---|---|
| Difference in SLP Breath Timing indices and measured in seconds and between Patients and Healthy Subjects | SLP breathing parameters derived from the movement of the thoracoabdominal (TA) wall during tidal breathing | Baseline |
| Difference in SLP Breath Timing Ratios between Patients and Healthy Subjects | SLP breathing parameters derived from the trace of movement over time of the thoracoabdominal (TA) wall during tidal breathing | Baseline |
| Difference in SLP derived Relative Contribution (measured in %) between Patients and Healthy Subjects | SLP breathing parameters derived from the movement of the thoracoabdominal (TA) wall during tidal breathing that describes the contribution of a region of the thoracoabdominal wall to total displacement | Baseline |
| Difference in SLP derived Phase (measured in degrees) between Patients and Healthy Subjects | SLP breathing parameters derived from the movement of the thoracoabdominal (TA) wall during tidal breathing that describes the contribution of a region of the thoracoabdominal wall to total displacement | Baseline |
| Difference in SLP derived displacement rate derived parameters (measured in distance per second) between Patients and Healthy Subjects | SLP breathing parameters derived from the trace of displacement rate over time of the thoracoabdominal (TA) wall during tidal breathing | Baseline |
| Difference in SLP displacement rate derived ratios between Patients and Healthy Subjects (measured in distance per second) between Patients and Healthy Subjects |
| Measure | Description | Time Frame |
|---|---|---|
| Forced Expiratory Volume in 1 second (FEV1) | Measurement of FEV1 | Baseline |
| Forced Vital Capacity (FVC) | Measurement of FVC | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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A range of diagnostic conditions that effect breathing and healthy normal subjects. The study will aim to recruit:
200 patients from different diagnostic groups between the ages of 0 and 80 100 healthy participants with no diagnosis of respiratory disease, between the ages of 0 and 80
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rachel Wilson, PhD | Contact | 01223 967 414 | rachel.wilson@pneumacare.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cambridge University Hospitals Foundation Trust | Recruiting | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15994402 | Background | Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. General considerations for lung function testing. Eur Respir J. 2005 Jul;26(1):153-61. doi: 10.1183/09031936.05.00034505. No abstract available. | |
| Background | de Boer WH, Lasenby J, Cameron J, Wareham R, Ahmad S, Roach C, Hills W, Iles R. SLP: a zero-contact non-invasive method for pulmonary function testing. In: Labrosse F, Zwiggelaar R, Liu Y, Tiddeman B, eds, Proceedings of the British Machine Vision Conference. BMVA Press, 2010; pp 85.1-85.12 | ||
| 6701820 |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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SLP breathing parameters ratios derived from the trace of displacement rate over time of the thoracoabdominal (TA) wall during tidal breathing
| Baseline |
| Background |
| Morgan MD, Gourlay AR, Denison DM. An optical method of studying the shape and movement of the chest wall in recumbent patients. Thorax. 1984 Feb;39(2):101-6. doi: 10.1136/thx.39.2.101. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |