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| Name | Class |
|---|---|
| Cambridge University Hospitals NHS Foundation Trust | OTHER |
| University of Cambridge | OTHER |
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Measurements of Structured Light Plethysmography (SLP) using a chest wall movement based method will be compared to those obtained by spirometry using a flow based pneumotachograph method. This study will enable validation of SLP in children and adults by allowing direct comparison of simultaneous measurements of breathing sequences using the two measurement techniques.
The investigators will also examine, in a group of normal adults, repeatability of the agreement between the two devices, and whether the agreement is affected by a change in tidal breathing parameters.
Measurements using the Structured Light Plethysmography method will be compared to those obtained by spirometry using a flow based pneumotachograph.
Spirometry is the gold standard for measuring lung function in both clinical support and research roles. Modern spirometers are high precision, reliable instruments enabling a large numbers of parameters relating to lung volumes and the rate of emptying the lungs during a forced expiration to be measured. The most common and accurate method to measure the patient's forced expiration is via pneumotachograph which measures the flow of air through a mouthpiece and integrates the signal to derive the volume expired.
Structured Light Plethysmography (SLP) system that measures changes of the chest and abdominal wall movement during breathing by modelling the thorax and abdominal surface defined by a projected structured light pattern which enables a grid of virtual parts to be formed, the movement of which is recorded by digital cameras. SLP provides non-contact assessment to provide lung function data utilising structured light technologies and enhanced imaging processing.
In this study direct comparison will be made of measurements recorded simultaneously using the two measuring devices in children and adults.
To examine repeatability of the agreement between tidal breathing parameters measured by two techniques, repeated measurements will be performed in each of a group of normal adult subjects. The investigators will also examine whether the agreement is affected by a change in tidal breathing parameters. To obtain a change in tidal breathing parameters, measurements will be recorded during resting spontaneous breathing and after a period of exercise to elevate Respiratory Rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breathing Sequence | Other | Simultaneous measurement using Structured Light Plethysmography and Pneumotachograph Spirometry during a period of tidal breathing followed by a forced respiratory manoeuvre. This sequence is repeated twice. |
|
| Agreement and repeatability Breathing Sequence | Other | Simultaneous measurement using Structured Light Plethysmography and Pneumotachograph Spirometry during a period of tidal breathing. This sequence is repeated one further time at rest, and once further time after an exercise test to elevate respiratory rate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Structured Light Plethysmography | Device | Non contact device that uses light to record displacement of the anterior thorax and abdomen region |
|
| Measure | Description | Time Frame |
|---|---|---|
| Forced Vital Capacity (FVC) measured in Litres | The volume of air a person can exhale during a maximal forced breath | 5 minutes |
| Forced Expiratory Volume in one second (FEV1) measured in litres per second | The volume of air a person can exhale in one second during a maximal forced breath | 5 minutes |
| Peak Expiratory Flow (PEF) measured in litres per second | The maximal flow a person can achieve during a maximal forced breath | 5 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory Waveform | Visual comparison of respiratory waveform shape and amplitude produced by pneumotachograph and SLP. | 5 minutes |
| Respiratory Rate (RR) measured in seconds | Tmings derived from the Respiratory Waveforms |
| Measure | Description | Time Frame |
|---|---|---|
| Inspiratory over Expiratory flow at 50 percent of tidal displacement (IE50) expressed at a ratio | Flow ratios derived from the Respiratory Waveforms | 5 minutes |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Karl Sylvester, PhD | Addenbrookes University Hospitals NHS Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cambridge University Hospitals Foundation Trust | Cambridge | Cambridgeshire | CB2 0QQ | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11334135 | Background | Stocks J, Godfrey S, Beardsmore C, Bar-Yishay E, Castile R; ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Plethysmographic measurements of lung volume and airway resistance. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society. Eur Respir J. 2001 Feb;17(2):302-12. doi: 10.1183/09031936.01.17203020. | |
| 11292125 |
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| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
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|
| Pneumotachograph Spirometry | Device | Device that measures airflow at the mouth using a mouthpiece |
|
| 5 minutes |
| Inspiratory Time (tI) measured in seconds | Timings derived from the Respiratory Waveforms | 5 minutes |
| Expiratory Time (tE) measured in seconds | Timings derived from the Respiratory Waveforms | 5 minutes |
| Total breath time (tTot) measured in seconds | Timings derived from the Respiratory Waveforms | 5 minutes |
| Inspiratory/expiratory ratio (tI/tE) expressed as a ratio | Timing ratios derived from the Respiratory Waveforms | 5 minutes |
| The duty cycle (tI/tTot) expressed as a ratio | Timing ratios derived from the Respiratory Waveforms | 5 minutes |
| Background |
| Bates JH, Schmalisch G, Filbrun D, Stocks J. Tidal breath analysis for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J. 2000 Dec;16(6):1180-92. doi: 10.1034/j.1399-3003.2000.16f26.x. |
| 7836125 | Background | Ferrigno G, Carnevali P, Aliverti A, Molteni F, Beulcke G, Pedotti A. Three-dimensional optical analysis of chest wall motion. J Appl Physiol (1985). 1994 Sep;77(3):1224-31. doi: 10.1152/jappl.1994.77.3.1224. |
| 9018522 | Background | Cala SJ, Kenyon CM, Ferrigno G, Carnevali P, Aliverti A, Pedotti A, Macklem PT, Rochester DF. Chest wall and lung volume estimation by optical reflectance motion analysis. J Appl Physiol (1985). 1996 Dec;81(6):2680-9. doi: 10.1152/jappl.1996.81.6.2680. |