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Futility
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The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRRT group | Active Comparator | the CRRT group receives continuous renal replacement therapy for acute kidney injury |
|
| IRRT group | Active Comparator | the IRRT group receives intermittent renal replacement therapy after termination of CRRT. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Renal replacement therapy | Device | Patients receive renal replacement therapy according to institutional standards |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound | During hemodialysis therapy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gabor Erdoes, MD | University of Berne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bern | Bern | 3010 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29562937 | Derived | Erdoes G, Uehlinger DE, Kobel B, Stucki MP, Wiest R, Stueber F, Fankhauser N, Jakob SM, Schefold JC. Cerebral microembolism in the critically ill with acute kidney injury (COMET-AKI trial): study protocol for a randomized controlled clinical trial. Trials. 2018 Mar 21;19(1):189. doi: 10.1186/s13063-018-2561-3. |
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| ID | Term |
|---|---|
| D020766 | Intracranial Embolism |
| ID | Term |
|---|---|
| D002542 | Intracranial Embolism and Thrombosis |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D006435 | Renal Dialysis |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D016060 | Sorption Detoxification |
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| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013923 | Thromboembolism |
| D016769 | Embolism and Thrombosis |