Cerebral Microembolism in the Critically Ill With Acute Kidney Injury

Cerebral Microembolism in the Critically Ill With Acute Kidney Injury: A Prospective Multi-Center Randomized Controlled Trial Comparing Continuous With Intermittent Renal Replacement Therapy.

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Inclusion Criteria:

• > 18 yrs.
• Signed IC

Exclusion Criteria:

• Heart disease (PFO, ASD, VSD, severe valvular disease)
• Atrial fibrillation
• Cerebrovascular pathology
• Missing temporal bone window
• Allergy to plastic contained in the investigative device (transcranial Doppler)
• Chronic kidney disease
• Pregnancy
• Participation in another study