Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients

Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.

please see above

Inclusion Criteria:

• all ICU patients requiring renal replacement therapy

Exclusion Criteria:

• patient denies informed consent
• patient not requiring intensive care therapy
• kidney transplanted patients
• chronic renal failure (serum creatinine > 3mg/dl)