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Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.
Aim: To compare the results of frozen thawed embryo transfers with and without GnRHa analogue support Primary end point: IR, PR, on going PR Secondary end point: hCH, E2 and progesterone levels 14 days after thawing
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Natural cycle, control | No Intervention | Treatment cycles with normal luteal support with progesteron | |
| Natural cycle, intervention | Experimental | Treatment cycles with normal luteal support with progesteron and a single dose of 0.1 mg triptorelin when the age of the embryo was 6 days: Intervention is the additional 0.1 mg triptorelin as described in the previous sentence. |
|
| Hormone replacement cycle, control | No Intervention | Standard hormone replacement cycle with estrogen and progesteron | |
| Hormone replacement cycle, intervention | Experimental | Standard hormone replacement cycle with estrogen and progesteron and a single dose of 0.1 mg triptorelin when the age of the embryo was 6 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Natural cycle: Triptorelin acetate 0.1 mg | Drug | A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in additon to standard micronized progesterone 400 mg vaginally |
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy rate | five weeks after the embryo transfer | |
| Implantation rate | five weeks after the embryo transfer | |
| Ongoing pregnancy rate | ten weeks after the embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| hCG- level | 14 days after thawing of the embryos |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Varpu Jokimaa, MD, PhD | Hospital District of the South-West Finland | Principal Investigator |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D017329 | Triptorelin Pamoate |
| ID | Term |
|---|---|
| D007987 | Gonadotropin-Releasing Hormone |
| D010906 | Pituitary Hormone-Releasing Hormones |
| D007028 | Hypothalamic Hormones |
| D036361 | Peptide Hormones |
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| Hormone replacement cycle and triptorelin acetate 0.1 mg | Drug | A single dose of triptorelin acetate 0.1 s.c. was giwen when the age of the transferred embryo was six days in addition to standard Estradiol and progesterone support |
|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |