The Use of Sennosides With Pico Salax in Bowel Preparation for Colonoscopy: a Study of Optimal Dose and Timing

The Use of Sennosides With Pico Salax in Bowel Preparation for Colonoscopy: a Study of Optimal Dose and Timing

The objective of this study is to evaluate sennosides as an adjunct to sodium picosulfate magnesium citrate (Pico Salax) in preparation for colonoscopy. We will compare different doses and administration times. The primary outcome is number of bowel motions produced. Secondary outcomes include the quality of bowel cleansing and patient tolerability.

We will compare different doses and administration times in patients booked for morning colonoscopy. The primary outcome is number of bowel motions produced in total by the sennosides. Secondary outcomes include the quality of bowel cleansing and patient tolerability.

Inclusion Criteria:

• Male and non-pregnant female patients 18 to 75 years of age inclusive
• Patients who require an outpatient colonoscopy with a split dose Pico-Salax prep

Exclusion Criteria:

• Colonoscopy requiring the use of a large volume prep (eg Colyte, PEG)
• Ileus or bowel obstruction
• Previous colorectal surgery
• Ascites
• Recognized renal impairment (defined as GFR less than normal in 3 months prior to enrolment)
• Pregnancy
• Recent (<6 months) myocardial infarction or unstable angina.