Partial Breast Irradiation for Low-risk Ductal Carcinoma In Situ After Breast-conserving Surgery

Phase II Study of Partial Breast Irradiation for Low-risk Ductal Carcinoma In Situ After Breast-conserving Surgery

This study is designed to evaluate the feasibility and safety of partial breast irradiation for low risk DCIS after breast-conserving surgery.

Randomized clinical trials have demonstrated that the recurrence of DCIS is low and most of the recurrence occurs around the tumor bed. Besides, cosmetic outcomes are reported better in partial breast irradiation group compared to whole breast irradiation group. However, whether or not partial breast irradiation is safety in DCIS is still unknown. The purpose of this study is to evaluate the feasibility and safety of partial breast irradiation for low risk DCIS after breast-conserving surgery.

Inclusion Criteria:

• Female
• 18~65 years old
• Pathologically confirmed DCIS, low- or intermediate- grade DCIS: (lesions of ≤2.5 cm diameter, resection margins of at least 3 mm, nuclei grade: 1-2), high grade DCIS: (lesions of ≤1 cm diameter, resection margins of at least 3 mm, nuclei grade: 3)
• Treated with breast conserving surgery
• Tumor bed is labeled with Titanium clips
• No malignancy history
• ECOG score 0~1
• Written informed consent

Exclusion Criteria:

• DCIS of both breast
• invasive breast cancer
• Multicentric disease
• Patients underwent mastectomy
• Previous radiation therapy of breast
• Medical contraindication for radiotherapy
• Pregnant or nursing
• suspicious calcification after surgery