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This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| theta-burst TMS | Experimental | Theta-Burst protocol for transcranial magnetic stimulation on dorsolateral prefrontal cortex (exact location to be determined using neuronavigation guided by Magnetic Resonance Imaging) |
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| sham theta-burst TMS | Sham Comparator | Sham protocol for theta-burst transcranial magnetic stimulation on dorsolateral prefrontal cortex (exact location to be determined using neuronavigation guided by Magnetic Resonance Imaging) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| theta-burst TMS | Device | This protocol involves short periods of pulse delivery in combination with long periods of silent intervals. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in functional connectivity following TMS administration using functional MRI | Changes in brain connectivity will be assessed by comparing functional MRI scans after theta-burst TMS and sham theta-burst TMS | One hour |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in brain metabolites following TMS administration using MR spectroscopy | Using MRI scans, changes in metabolites in the brain will be assessed following theta-burst TMS and sham TMS | One hour |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarina Iwabuchi, PhD | University of Nottingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sarina Iwabuchi | Nottingham | Nottinghamshire | NG7 2TU | United Kingdom |
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| sham theta-burst TMS | Device | This protocol delivers theta-burst pulses from a sham device (i.e. at same speed and timeframe but without the magnetic output) |
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