Cryoprobe Transbronchial Lung Biospy in Patients With Mechanical Ventilation

The purpose of this study is to evaluate the the diagnostic yield and safety of transbronchial lung biopsies (TBLB) with cryoprobe in patients with mechanical ventilation.

Inclusion Criteria:

• ≥18 years old
• Patients with mechanical ventilation.
• Patients with diffuse lung disease of unknown etiology.
• Need for confirming/excluding a diagnosis, with therapeutical and prognosis implications.
• Inform consent signed by family.

Exclusion Criteria:

• Use of anticoagulant therapy or presence of a coagulation disorder (abnormal platelets counts, international normalized ratio > 1.5).
• Comorbidities that could increase the risk of the TBLB.
• Bullous emphysema.
• Hemoptysis, pneumothorax.
• Severe respiratory insufficiency requiring PEEP >12 cm H2O