Diagnostic Yield and Safety of Transbronchial Lung Biopsy Using Cryoprobes Versus Conventional Forceps. A Multicenter Study

Diagnostic Yield and Safety of Transbronchial Lung Biopsy Using Cryoprobes Versus Conventional Forceps. A Multicenter Study

The purpose of this study is to evaluate the diagnostic yield and safety of transbronchial lung biopsies (TBLB) with cryoprobe versus conventional forceps in patients with diffuse lung disease.

Inclusion Criteria:

• >18 years old
• Patients with diffuse lung disease candidate to study with transbronchial lung biopsy (TBLB).
• Inform consent signed.

Exclusion Criteria:

• FEV1 <40% of reference value.
• Respiratory insufficiency (pO2 <60 mmHg or pCO2 >45 mmHg).
• Use of anticoagulant therapy or presence of a coagulation (disorder abnormal platelets counts, international normalized ratio > 1.5).
• Bullous emphysema.
• Pulmonary arterial hypertension.
• Hypersensitivity to anaesthetic and sedative drugs (lidocaine, midazolam, propofol, remifentanyl).
• Psychiatric illness.
• Comorbidities that could increase the risk of the TBLB.
• Pregnancy.