The purpose of this study is to see if exercise fitness testing is feasible and safe in persons over 21 years of age who have been diagnosed with a hematological malignancy and are scheduled to undergo a hematopoietic stem cell transplant (HCT). Assessments in this study will look at the capacity of the body before transplantation to see if these measures can help predict how patients do after transplant.

Inclusion Criteria:

• Patients with MSK histologically confirmed hematologic malignancy
• Scheduled for autologous or allogenic HCT at MSKCC
• ≥21 years old
• ECOG performance status of 0 or 1
• Completion of baseline CPET
• Willing to comply with protocol related procedures

Exclusion Criteria:

• Any of the following absolute contraindications to cardiopulmonary exercise testing

  • Acute myocardial Infarction (within 3-5 days of any planned study procedures)
  • Unstable angina
  • Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
  • Recurrent syncope
  • Active endocarditis
  • Acute myocarditis or pericarditis
  • Symptomatic severe aortic stenosis
  • Uncontrolled heart failure
  • Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
  • Thrombosis of lower extremities
  • Suspected dissecting aneurysm
  • Uncontrolled asthma
  • Pulmonary edema
  • Respiratory failure
  • Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis)
  • Presence of any other concurrent, actively treated malignancy;
  • History of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer);
  • Room air desaturation at rest ≤85%
  • Mental impairment leading to inability to cooperate

Potentially eligible will be identified through and recruited from the Adult Bone Marrow Transplantation clinics at MSK.