Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation

Cardio-Oncology Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation

To assess the feasibility and preliminary effectiveness of a Cardio-Oncology Prehabilitation program in patients at high-risk of developing Cardiovascular (CV) events in improving Cardiorespiratory fitness (CRF) and reducing acute CV complications in Hematopoietic stem cell transplant (HSCT) recipients.

Inclusion Criteria:

• Adult 18 years or older
• Referred for HSCT evaluation
• Presence of least one CV risk factor at enrollment (hypertension, hyperlipidemia, atrial fibrillation, obesity, heart failure, history of coronary artery disease, diabetes)
• Able to ambulate unassisted
• Ability to understand and the willingness to sign a written informed consent
• Ability to use Polar Flow heart rate application

Exclusion Criteria:

• Severe anemia (hemoglobin <7 gm/dl)
• Untreated high-risk coronary artery disease (left main, triple vessel disease)
• Severe aortic stenosis
• Recent fracture as assessed via self-report
• Gross balance deficits
• Severe pain with basic movement
• Unable to ambulate unassisted or exercise
• NYHA class IV heart failure
• Adults unable to give consent, pregnant women, and prisoners are excluded from this study.