Efficacy and Safety of Lidocaine Infusion Treatment in Management of Neuropathic Pain

Efficacy and Safety of Lidocaine Infusion Treatment in Management of Neuropathic Pain: Randomized, Controlled, Comparative Study

The investigators conducted a randomized, Double blind, and Controlled Study to evaluate the Efficacy and safety of Lidocaine Infusion Treatment in Management of Neuropathic pain.

The investigators expect pain improvement after treatment with 3 mg/kg of lidocaine, continuously infused in normal saline 250 ml.

Inclusion Criteria:

• postherpetic neuralgia, diabetic polyneuropathy, peripheral neuropathy
• NRS score > 4
• stable oral medication during the 1 month trial period
• volunteers with informed consent

Exclusion Criteria:

• pregnancy, breastfeeding, possibility of pregnancy
• pain from causes other than upper 3 indications
• hypersensitivity to lidocaine or other local anesthetics
• important disease of heart, kidney, liver or incurable disease that may affect the assessment of adverse effects, or may interfere with the completion of study
• severe conduction block
• history of other interventions that may affect the study
• Enrollment in other clinical trials within 30 days
• otherwise not suitable to study