Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain

Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain : A Pilot Study

The purpose of this study to evaluated Long term outcome after serial Lidocaine infusion when compared with placebo in peripheral neuropathic pain patients in acute stage (less than 6 months) at 3 months after first time of infusion

Peripheral nerve injury may give rise to severe and long-lasting types of pains which are often resistant to treatment such as opioid, tricyclic antidepressant or anticonvulsant. Lidocaine infusion has been the one of intractable neuropathic pain treatment . My hypothesis the serial lidocaine infusion can adequate pain control and can prevent chronic pain (central sensitisation). Therefore, we designed this prospective, randomised, double-blind, controlled study to evaluate the efficacy of serial lidocaine infusion in peripheral neuropathic pain compared with placebo in long term outcome (at 3 month).

Inclusion Criteria:

• Peripheral neuropathic pain from peripheral nerve injury within 6 months after injury
• Well understand to Thai language in writing or listening

Exclusion Criteria:

• Underlying Heart disease or Arrhythmia
• Allergy to lidocaine, Gabapentin, Carbamazepine, tramadol
• History of epilepsy
• History of lidocaine used
• Underlying Psychiatric disease
• History of drug abuse
• Pregnancy and nursing