Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device

Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device

This study has two main goals :

• to investigate the impact of aging on cortical excitability (CE)
• to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.

A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.

Inclusion Criteria:

• male or female
• age 18-75
• signed informed consent
• normal physical examination

Exclusion Criteria:

• less 18 or more 75 years of age
• contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
• severe physical disease
• treatment with psychotropic drugs
• overt psychiatric disease
• alcohol consumption before the examination