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This study has two main goals :
A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| state dependency TMS | Other | TMS performed at rest and during a cognitive/emotional task |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TMS "Magpro®, Magventure Inc" device | Device |
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| Measure | Description | Time Frame |
|---|---|---|
| Amplitudes of Motor evoked Potentials (µV) for ICI and ICF. | Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations. Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission. | Participants will be followed for an expected average of one month |
| Durations of Cortical Silent Period (ms) | Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured. | Participants will be followed for an expected average of one month |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thierry BOUGEROL, MD, PhD | University of Grenoble | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry & Neurology - University Hospital Grenoble | Grenoble | 38000 | France |
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