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This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows reduction of tidal volume and plateau pressure. Systemic Inflammatory Response and Safety Variables will also be analysed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RRT plus ECCO2R | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RRT plus ECCO2R | Device | Patients with acute kidney injury will be treated with Renal replacement therapy associated to extracorporeal carbon dioxide removal in a single treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Achievement of tidal volume reduction to 4 mL/kg while maintaining pH and PaCO2 to ± 20% of baseline values | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of inflammatory mediators release in plasma samples of patients | Plasma Concentrations of interleukin 6, interleukin 8, interleukin 1 beta, tumor necrosis factor alpha | 72 hours |
| Assessment of the changes in pH |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedaliera Città della Salute e della Scienza di Torino | Turin | 10126 | Italy |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| 72 hours |
| Assessment of the changes in PaCO2 | 72 hours |
| Assessment of the changes in PaO2 | 72 hours |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |