Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).

Recurrent respiratory papillomatosis (RRP) is a chronic viral disease, which affects children and adults as well. It is characterised by grow of squamous cell tumours on mucosa of aerodigestive tract, with predilection for the larynx. The disease is caused by the human papillomavirus (HPV). However, in contrast to the low incidence of RRP, HPV prevalence is common. It is indicated that other factors may contribute to the pathogenesis of RRP. One such factor might be extraesophageal reflux (EER). We investigated whether patients with RRP suffer more often from EER.

Inclusion Criteria:

• age 1-75 years
• cooperating patients with laryngeal papillomatosis
• patients tolerating impedance probe
• signed informed consent, consent with the examinations
• control group of patients with a cyst or vocal cord polyp (reflux finding score 0-2) and/or patients indicated to augmentation, medialization or lateralization of the vocal cords

Exclusion Criteria:

• patients non-tolerating impedance catheter
• patients who do not understand Czech language
• patients who do not proclaim consent with enrolment into the study
• patients who do not proclaim consent with the planned examinations
• patients after surgical treatment of tumour of the swallowing or respiratory tract