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The purpose of this study is to assess the effects of physical exercise, associated or not with venous compression of the leg, on obstructive sleep apnea (OSA) severity and upper airway resistance in obese teenagers. Half of the participants will undergo physical exercise and compression socks program, and the other half of subjects will undergo physical exercise program without compression socks.
Obesity is an important factor of OSA development in children and teenagers, and physical activity is a relevant alternative to promote OSA decrease with ou without weight loss.
Physical activity, beyond the improvement of body composition and exercise cardiorespiratory capacity, restricts fluid retaining in the lower limb of the leg by the activation of musculovenous pump. Fluid retaining is involved in OSA severity because of nocturnal fluid shift from legs to rostral zone which promotes pharyngeal oedema development and upper airway collapsibility.
It has been previously shown that venous compression leads to beneficial fluid regulation in OSA subjects and appears as an efficient tool in OSA management.
To the investigators knowledge no study assess the impact of the cumulative effect of physical and venous compression program on upper airway resistances in obese teenager with OSA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interventional group | Experimental | Physical activity program coupled with compression socks wearing during 3 months. |
|
| control group | Active Comparator | Physical activity program without compression socks during 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Interventional group | Other | Venous compression leads to beneficial fluid regulation in OSA participants and appears as an efficient tool in OSA management. To the investigators knowledge no study assess the impact of the cumulative effect of physical and venous compression program on upper airway resistances in obese teenager with OSA. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Obstructive sleep apnea severity at 3 months. | Obstructive Sleep Apnea change will be assessed with polysomnography system at baseline and after three months | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Measure | Description | Time Frame |
|---|---|---|
| Upper airway resistances | upper airway resistance will be assessed by acoustic method | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Fluid shift | fluid shift will be assessed by bioimpedance analysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de soins de suite et de réadaptation La Beline | Salins-les-Bains | 39110 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32008915 | Derived | Roche J, Corgosinho FC, Damaso AR, Isacco L, Miguet M, Fillon A, Guyon A, Moreira GA, Pradella-Hallinan M, Tufik S, Tulio de Mello M, Gillet V, Pereira B, Duclos M, Boirie Y, Masurier J, Franco P, Thivel D, Mougin F. Sleep-disordered breathing in adolescents with obesity: When does it start to affect cardiometabolic health? Nutr Metab Cardiovasc Dis. 2020 Apr 12;30(4):683-693. doi: 10.1016/j.numecd.2019.12.003. Epub 2019 Dec 16. | |
| 29852904 |
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| ID | Term |
|---|---|
| D063766 | Pediatric Obesity |
| D020181 | Sleep Apnea, Obstructive |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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|
| Control group | Other | Standard obesity care with physical activity program |
|
| This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Calf and neck circumferences | Calf and neck circumferences will be assessed with nonelastic tape | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Calf and neck circumferences | Calf and neck circumferences will be assessed by plethysmography | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Anthropometric parameters | weight, height, waist and hip circumferences (body weight scale, standing stadiometer and non-elastic tape) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Body composition | fat mass, fat free mass ( by bioimpedance analysis) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Pulmonary function during exercise | Incremental maximal exercise in cycling ergometer with respiratory gas assessment (metamax) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Metabolic responses | Glucose, LDL-Cholesterol, HDL-Cholesterol, Total Cholesterol, Triglycerides (ELISA and RIA technics) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Hormonal responses | Insulin, leptin, adiponectin, catecholamines (ELISA and RIA technics) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Inflammatory responses | C-reactive protein (ELISA and RIA technics) | This study includes 2 assessments : baseline (T0) and 3 months (T3) |
| Derived |
| Roche J, Gillet V, Perret F, Mougin F. Obstructive Sleep Apnea and Sleep Architecture in Adolescents With Severe Obesity: Effects of a 9-Month Lifestyle Modification Program Based on Regular Exercise and a Balanced Diet. J Clin Sleep Med. 2018 Jun 15;14(6):967-976. doi: 10.5664/jcsm.7162. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012891 | Sleep Apnea Syndromes |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D001519 | Behavior |
| D008722 | Methods |