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| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A00490-49 | Other Identifier | ANSM |
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Sleep apnoea affects more than 20% of people over 65 years and is largely underdiagnosed. It does multiply tenfold the occurrence of vascular events, particularly stroke. While Continuous Positive Airway Pressure (CPAP) is currently the Gold standard treatment to prevent cerebrovascular and cardiovascular events, with a major clinical benefit, long term adherence to CPAP is a significant problem and search for alternative treatment is essential.
The investigators hypothesize that long-term exercise training would allow to reduce significantly sleep apnoea syndrome severity. Thus, in this study, the investigators will compare evolution of Apnoea Hypopnea Index (AHI) in an exercise trained group performed through in a national based non-profit organization (Fédération Française d'éducation Physique et de Gymnastique Volontaire (FFEPGV)) using a medical established program (NeuroGyV) during nine months against a control group receiving only standard dietetic and physical activity counseling.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Training | Experimental | In this group, patients will perform 3 sessions of one hour per week of the "NeuroGyV" training program. It is a physical activity program with one session of Nordic walking, one session of "aquagym" and one session of gymnastic. Program lasts 9 months. |
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| Control | Other | In this group, patients will receive only diets and physical activity counselling |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Training | Other |
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| |
| Control |
| Measure | Description | Time Frame |
|---|---|---|
| Final polysomnography | Percentage of patients with AHI < 15/hour through polysomnography assessment after nine months of follow-up in the training and the control groups | 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| First intermediate polysomnography | Percentage of patients with AHI<15/hour through polysomnography assessment after three months of follow-up in the training and the control groups. | 3 months |
| Second intermediate polysomnography |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Frederic ROCHE, MD - PhD | CHU de Saint-Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Saint-Etienne | Saint-Etienne | 42000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30361248 | Derived | Berger M, Barthelemy JC, Hupin D, Raffin J, Dupre C, Labeix P, Costes F, Gaspoz JM, Roche F. Benefits of supervised community physical activity in obstructive sleep apnoea. Eur Respir J. 2018 Nov 22;52(5):1801592. doi: 10.1183/13993003.01592-2018. Print 2018 Nov. No abstract available. |
| Label | URL |
|---|---|
| Website of the FFEPGV (in french) | View source |
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| ID | Term |
|---|---|
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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| Other |
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Percentage of patients with AHI<15/hour through polysomnography assessment after six months of follow-up in the training and the control groups.
| 6 months |
| High frequency | Correlation between change in AHI and change in high frequency (HF) of spectral analysis of heart rate variability (parasympathetic index) at 9 months of follow-up in the 2 groups | 9 months |
| Maximal aerobic capacity (VO2Max) | Correlation between the change in VO2max during stress test, walking distance during 6 minutes and AHI in the two groups | 9 months |
| Population Physical Activity questionnaire (POPAQ) | Correlation between the change in daily physical activity energy expenditure (estimated by the POPAQ questionnaire) and AHI in the two groups | 9 months |
| Daily physical activity energy expenditure | Correlation between the daily physical activity energy expenditure (estimated directly by an actimetry sensor for 7 days) and AHI in the two groups | 9 months |
| Epworth sleepiness Scale | Comparison of the variation of Epworth Sleepiness Scale (ESS) after 9 months follow-up for the two groups | 9 months |
| Pittsburgh questionnaire | Comparison of the variation of Pittsburgh questionnaire after 9 months follow-up for the two groups | 9 months |
| Berlin questionnaire | Comparison of the variation of Berlin questionnaire after 9 months follow-up for the two groups | 9 months |
| Blood pressure - Baroreflex | Measure of autonomic function (parasympathetic activity) - quantified via changes in blood pressure | 9 months |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |