Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

A Study of the Effect of Oral, Multiple-Dose 300 mg and 900 mg Gemcabene (CI-1027) Administration on the Steady-State Pharmacokinetics of Atorvastatin 80 mg

The purpose of this study is to determine the effect of gemcabene on the pharmacokinetics of atorvastatin 80 mg

Inclusion Criteria:

• Males and Females
• 18-65 years of age
• Good health as determined by medical history, physical examination, vital signs, ECG, and clinical laboratory measurements;
• Body weight 45 kg or greater, with a body mass index (BMI) ≤ 35 kg/m² (weight [kg]/height[meters]²)

Exclusion Criteria:

• If female, of childbearing potential or lactation
• History of significant adverse reaction to any lipid-lowering agent