Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy Volunteers

A Study to Evaluate the Effects of Gemcabene on the Steady-State Pharmacokinetics and Pharmacodynamics of Simvastatin in Healthy Volunteers

The purpose of this study is to determine the effect of gemcabene on the pharmacokinetics of simvastatin 80 mg.

Inclusion Criteria:

• Males and Females
• >18 years of age
• Body weight 45 kg or greater

Exclusion Criteria:

• If female, of childbearing potential or lactation
• History of significant adverse reaction to any fibrate lipid-lowering agent or HMG-CoA reductase inhibitor