The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate

The Effect of GLP-1 on Postprandial Glucagon Secretion During Prolonged and Intermittent Stimulation of the GLP-1 Receptor Independent of The Gastric Emptying Rate. A Randomized, Open-label Study in People With Type 1 Diabetes

Aim: To investigate the glucagonostatic effect of glucagon-like peptide-1 (GLP-1) independent of the gastric emptying rate.

Aim: To investigate the glucagonostatic effects of glucagon-like peptide-1 (GLP-1) during prolonged and intermittent stimulation of the GLP-1 receptor independent of the gastric emptying rate. Glucagon concentrations will be measured following a liquid meal administered in duodenum at baseline and after exenatide, and liraglutide treatment.

Inclusion Criteria:

• Type 1 Diabetes
• >18 years
• No residual beta-cell function (stimulated C-peptide < 60 pmol)

Exclusion Criteria:

• Pancreatitis
• gastroparesis
• history of alcohol and/or drug abuse
• pregnancy and lactation
• other medical or psychological condition that made the patient unsuitable for study participation according to the investigators´ assessment
• contraindications to gastroscopy
• cancer (unless in complete remission > five years)