Effect of GLP-1 on Insulin-dose, Risk of Hypoglycemia and Gastric Emptying Rate in Patients With Type 1 Diabetes

Effect of GLP-1 on Insulin-dose, Risk of Hypoglycemia and Gastric Emptying Rate in Patients With Type 1 Diabetes

The aim of the study is to investigate the effect of Victoza (a GLP-1 receptor agonist)on insulin-dose, risk of hypoglycemia and gastric emptying rate during hypoglycemia in patients with type 1 diabetes.

Inclusion Criteria:

• age 18-50y,
• BMI 18-27,
• caucasian origin,
• type 1 diabetes diagnosed between age 5 and age 40,
• no known diabetes complications or cardiovascular diseases,
• no medication known to influence glucose homeostasis,
• no pregnancy

Exclusion Criteria:

• diabetes complications,
• autonomous nerve dysfunction,
• anaemia,
• HbA1c < 8.5% at screening,
• estimated by the investigator to be incapable of completing the trial.