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In the proposed study, investigators aim to investigate the role of interpersonal trust in the conditioned placebo analgesia process with healthy male subjects in a standardized experimental heat pain paradigm.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | All participants will also be introduced to the control cream: "This cream is a control cream". |
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| Placebo | Sham Comparator | All participants will then be introduced to an analgesia expectation: "This cream is a powerful pain killer", while receiving an inert cream. In this study participants will be told that they will receive a potent painkiller as well as a control cream. Making use of placebo cream is an established method to induce placebo expectations . Moreover, to increase the analgesic effect, heat pain stimuli intensity will be surreptitiously lowered for the placebo trials to a temperature corresponding to 30% of the VAS intensity and to 60% for the control trials. As the occurrence of a placebo response is highly dependent on expectations, the deceptive procedure described above is used in order to maximally enhance expectations and therefore placebo response. Participants will be debriefed after the completion of study participation. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale (VAS) rating (Intensity + unpleasantness of pain) | 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale (VAS) rating (trust) | 2 hours | |
| State-Trait-Anxiety (STAI- X1) | 2 hours | |
| State Trait Anger Expression (STAXI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens Gaab, Prof | Clinical Psychology and Psychotherapy, Department of Psychology, University of Basel | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Basel | Basel | 4055 | Switzerland |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 2 hours |
| Questionnaire about expectations (Erwartungsfragebogen) | 2 hours |
| Questionnaire about the investigator (Fragebogen zum Versuchsleiter | 2 hours |
| sociodemographic questionnaire (Soziodemographischer Fragebogen (SES)) | 2 hours |
| Questionnaire about Self-assessment of partnership binding (Bochumer Bindungsfragebogen - BoBi) | 2 hours |
| State-Trait-Anxiety (STAI-X2 ) | 2 hours |