Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults

Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults - A Randomized Single Blinded Clinical Trail

Open Label Placebo application has been shown to be effective in treatment of chronic pain (low back pain) and disease like the irritable bowel Syndrome. Data about effects on acute pain are spare.

The study investigates the effect of an open-label Placebo (substance without a medical active component) application on acute pain, evoked via a artificial pain model in healthy male volunteers. 32 healthy male volunteers are recruited.

Inclusion Criteria:

• Healthy male volunteers (American Society of Anaesthesiologist's Class I or II)
• Body mass index between 18 and 25kg/m2
• Able to understand the study and the NRS scale
• Able to give informed consent

Exclusion Criteria:

• Recreational drug abuse
• Regularly taking medication potentially interfere with pain sensation (analgesics, antihistamines and calcium and potassium channel blockers)
• Neuropathy
• Chronic pain
• Neuromuscular or psychiatric disease
• Known or suspected kidney or liver disease