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| Name | Class |
|---|---|
| Admescope Ltd | INDUSTRY |
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Constipation is common in pregnant women. Surgery, anaesthesia and opioid analgesics may further impair bowel function. The aim of the present study was to evaluate if oxycodone-naloxone combination compared to oxycodone reduced bowel dysfunction in patients undergoing caesarean section.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Oxycodone | Active Comparator | Oxycodone 10 mg prolonged release tablet twice a day after caesarean section |
|
| Oxycodone-naloxone | Experimental | Oxycodone-naloxone 10/5 mg prolonged release tablet twice a day after caesarean section |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Caesarean section | Procedure | After caesarean section oxycodone or oxycodone-naloxone prolonged release tablet twice a day is started for pain medication |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with opioid induced bowel dysfunction assessed with bowel function index | time from the first drug intake up to three weeks postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Oxycodone concentrations in maternal plasma | time before the first drug intake to the day when patient leaves the hospital up to maximum of seven days postoperatively |
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Inclusion Criteria:
• elective caesarean section in spinal anaesthesia
Exclusion Criteria:
• not normal or full term pregnancy
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| Name | Affiliation | Role |
|---|---|---|
| Merja Kokki, MD, PhD | Kuopio University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kuopio University Hospital | Kuopio | Northern Savonia | 70029 | Finland |
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| ID | Term |
|---|---|
| D003248 | Constipation |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
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| ID | Term |
|---|---|
| D002585 | Cesarean Section |
| D010098 | Oxycodone |
| C557247 | oxycodone naloxone combination |
| ID | Term |
|---|---|
| D036861 | Delivery, Obstetric |
| D013513 | Obstetric Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D003061 | Codeine |
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| Oxycodone | Drug |
|
| oxycodone-naloxone | Drug |
|
| D010335 | Pathologic Processes |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |