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Lung transplantation (LTx) , DNA-based testing.
Performance of DNA-based testing of bacterial and fungal pathogens in comparison to standard testing.
Experimental intervention: DNA-based testing of BAL fluid.
Cohen's kappa of any pathogen isolation by DNA-based testing vs. standard cultures in comparison to the final diagnosis of non-viral lower respiratory tract infection.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimental Intervention: DNA-based testing of BAL fluid | Other | DNA based testing needs 4.5 hours lab time in addition to standard testing |
| Measure | Description | Time Frame |
|---|---|---|
| Cohen's kappa of any pathogen isolation by DNA-based testing vs. standard cultures in comparison to the final diagnosis of non-viral lower respiratory tract infection | Cohen's kappa measures the agreement between methods and the final clinical diagnosis. Both methods (DNA-based testing and standard cultures) will result in isolation of a non-viral pathogen or no isolation of a pathogen. A final clinical diagnosis will classify patients clinically in two categories as non-viral lower respiratory tract infection or no non-viral lower respiratory tract infection usually made 48-72 hours made after sampling. Cohen's kappa will be compared between the two methods. | 6 month |
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Inclusion Criteria:
Exclusion Criteria:
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Lung transplant recipients with suspected non-viral lower respiratory tract infection
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nora Drick, MD | Contact | 0511 532 | 4601 | drick.nora@mh-hannover.de |
| Hoyer Susanne | Contact | 0511 532 | 4601 | hoyer.susanne@mh-hannover.de |
| Name | Affiliation | Role |
|---|---|---|
| Jens Gottlieb, Prof. Dr. | Hannover Medical School | Principal Investigator |
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Bronchoalveolar lavage