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The aim of this study is to show presence of cognitive and emotional factors on the beginning and persistence of auditory hallucinations in non-psychotic children. Investigators will describe a significant link between this factors and hallucinations in a sample of non-psychotic children. The results of this sample will be comparing to another group of children of the same age, sex and diagnosis, but without hallucination. Finally, investigators will control the persistence of hallucination on the first group after a six month period.
Background: Hallucinations are a common symptom in pediatric population without psychotic syndrome. Vulnerability, co morbidity and risk factor are already been described. Investigators will study the cognitive and emotional factors on the beginning and persistence of auditory hallucinations in non-psychotic children. The goal of the study is to find a social cognition our emotional impairment to explain auditory hallucinations without psychotic symptoms. Methods: Sample of out non-psychotic patients aged six to eighteen years old with auditory hallucinations were recruited with a self report scale created for this study. Mini International Neuropsychiatric Interview (MINI)-kids interview and "psychosis" section od Kiddie-SADS (Schedule for Affective Disorders and Schizophrenia for school age chidlren) were conducted to determine Diagnostic and Statistical Manual of Mental Disorders (DSM) IV diagnoses. All children patient were spend specifics social cognition (NeuroPsychologic assessment NEPSY II) and emotional (ifferential Emotions Scale (DES) IV, Beliefs About Voices Questionnaire Revised (BAVQ-R)) scales. Each child results will be compared to child result of the same age, sex and diagnosis but without hallucination that passed the same specifics scales. All of child will be control after a six month period to evaluate auditory hallucination persistence and diagnosis evolution. The total period of the study will be twelve month.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with auditory hallucination | Experimental | Patients with auditory hallucination: Evaluation at time 0 and 6 month after of:
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| Patients without auditory hallucination | Placebo Comparator | Patients without auditory hallucination: Evaluation at time 0 and 6 month after of:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patients with auditory hallucination | Behavioral | Patients with auditory hallucination (20 for each arm): Evaluation at time 0 and 6 month after of:
|
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of the score of theory of mind | The social cognitive marker will be evaluate by NeuroPsychologic assessment NEPSY II for theory of mind | Change from baseline 6 month later |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of the score of auditory hallucinations persistence | Evaluation of auditory hallucinations persistence with a self report scale using in recruiting criteria. | Change from baseline 6 month later |
| Evolution of the score of Mental Disorder |
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Inclusion Criteria:
Twenty participants included with auditory hallucination:
Twenty participants included without auditory hallucination:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Valérie BONNARD-COUTON, MD | Fondation Lenval | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Lenval | Nice | 06200 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34625214 | Derived | Dumas LE, Bonnard-Couton V, Golse B, Askenazy F. [Identifying cognitive and emotional markers in relation to auditory-verbal hallucinations in pediatric population: Physalis study]. Encephale. 2022 Oct;48(5):546-554. doi: 10.1016/j.encep.2021.06.010. Epub 2021 Oct 5. French. |
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| ID | Term |
|---|---|
| D006212 | Hallucinations |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Patients without auditory hallucination | Behavioral | Patients without auditory hallucination (20 for each arm): Evaluation at time 0 and 6 month after of:
|
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Evaluation of diagnosis of Mental Disorder with Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria using MINI-Kids (Mini International Neuropsychiatric Interview )
| Change from baseline 6 month later |
| Evaluation of the score of Psychosis | Evaluation of diagnosis of psychosis with DSM-IV (Diagnostic and Statistical Manual of Mental Disorders ) criteria using "Psychosis" section of Kiddie-SADS (Schedule for Affective Disorders and Schizophrenia for school age chidlren) | Change from baseline 6 month later |
| Evolution of the score of individual stability | The evaluation of the the emotional marker will be performed with the Differential emotion scale IV (DES IV): emotional individual stability | Change from baseline 6 month later |
| Evolution of measure of recognition of the feelings | The measure of recognition of the feelings will be performed by the score: The social cognitive marker (NEPSY II) | Change from baseline 6 month later |
| Evolution of auditory measure of patients' emotional | The auditory measure will be performed by the score: The social cognitive marker (NEPSY II) | Change from baseline 6 month later |
| Evolution of Emotional real-life experience of the hallucination | The Emotional real-life experience of the hallucination will be performed by the score: The Revised Beliefs About Voices Questionnaire (BAVQ-R) | Change from baseline 6 month later |
| Evolution of the score of affect recognition | The social cognitive marker will be evaluate by NeuroPsychologic assessment NEPSY II for theory of affect recognition | Change from baseline 6 month later |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |