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| ID | Type | Description | Link |
|---|---|---|---|
| NL42959.041.13 | Other Identifier | Toetsingonline |
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| Name | Class |
|---|---|
| University Medical Center Groningen | OTHER |
| Universitair Ziekenhuis Brussel | OTHER |
| Parnassia Groep | OTHER |
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Psychotic symptoms (hallucinations and delusions) are present in several psychiatric and neurological disorders as well as in the general population. Effective treatment strategies for these symptoms in all patients are lacking and treatment-response can presently not be predicted. To date, the exact pathophysiological mechanism of these symptoms remains unknown. By investigating (subtypes) of hallucinations and delusions in all populations, a common pathway may be found, leading to more effective treatment options. Alternatively, different subtypes may be associated with different pathophysiological mechanisms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with schizophrenia | With and without hallucinations | ||
| Patients with borderline personality disorder | With and without hallucinations | ||
| Patients with hearing impairment | With and without hallucinations | ||
| Patients with visual loss | With and without hallucinations | ||
| Patients with Parkinson's Disease | With and without hallucinations | ||
| Patients with Alzheimer's Disease | With and without hallucinations | ||
| Patients with dementia with Lewy Bodies | With and without hallucinations | ||
| Patients with Posttraumatic Stress Disorder |
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| Measure | Description | Time Frame |
|---|---|---|
| The number of clusters of patients with shared symptom profiles as determined by latent class analysis, and the difference in scores on cognitive assessment between these identified clusters. | Three years |
| Measure | Description | Time Frame |
|---|---|---|
| The internal consistency, test-retest reliability, inter-rater reliability, criterion validity and construct validity of a newly developed questionnaire. | Two years | |
| The difference in scores on cognitive assessment between participant groups with and without psychotic symptoms. |
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Inclusion Criteria:
Exclusion Criteria:
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We aim to include subjects of each of the following diagnostic groups, both with and without psychotic symptoms:
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mascha M.J. Linszen, MD | Contact | +31887557468 | m.m.j.linszen@umcutrecht.nl | |
| Sophie M. Heringa, PhD | Contact | s.m.heringa@umcutrecht.nl |
| Name | Affiliation | Role |
|---|---|---|
| Iris Sommer, Prof, MD, PhD | UMC Utrecht | Principal Investigator |
| Teus van Laar, MD, PhD | UMC Groningen | Principal Investigator |
| Philip Scheltens, Prof, MD, PhD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VU Medical Center | Recruiting | Amsterdam | Netherlands |
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| ID | Term |
|---|---|
| D006212 | Hallucinations |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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With and without hallucinations |
| Patients with delirium | With and without hallucinations |
| Healthy participants | With and without hallucinations |
| Patients with mood disorder | With and without hallucinations |
| Three years |
| Amsterdam UMC, location VUmc |
| Principal Investigator |
| Karin Slotema, MD, PhD | Parnassia Groep | Principal Investigator |
| UMC Groningen | Not yet recruiting | Groningen | Netherlands |
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| Parnassia Bavo Groep | Recruiting | The Hague | Netherlands |
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| UMC Utrecht | Recruiting | Utrecht | Netherlands |
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| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |