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It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning.
The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carotid Baroreflex measurements | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stimulation of the carotid baroreceptors with a pressure system | Procedure | In each decubitus, trains of stimuli 8 (-80, -60, -40, -20, 0, 10, 20 and 40 Torr), with a duration of 500 milliseconds each, will be applied using a positive and negative pressure system placed around the neck of the subject. |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial flow in Common Carotid Artery (EchoDoppler) | Measurements of Common Carotid Artery Blood Flow in Cm/s | baseline |
| Arterial flow in Internal Carotid Artery (EchoDoppler) | Measurements of Internal Carotid Artery Blood Flow in Cm/s | Baseline |
| Arterial flow in External Carotid Artery (EchoDoppler) | Measurements of External Carotid Artery Blood Flow in Cm/s | Baseline |
| Arterial flow in Vertebral Artery (EchoDoppler) | Measurements of Vertebral Artery Blood Flow in Cm/s | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratoire de Physiologie, CHU de Caen | Recruiting | Caen | 14000 | France |
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