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| Name | Class |
|---|---|
| Novespace | INDUSTRY |
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Main objective of the experiment is threefold: 1) to technically test a device for central blood pressure estimation for its applicability in a spaceflight-related environment and on the International Space Station. 2) Furthermore the objective is to compare central blood pressure estimates based on arterial pressure readings of different peripheral arteries. For central blood pressure estimation mathematical transfer functions as described by Karamanoglu and colleagues (11) will be used. 3) Finally the experiments' objective is to simultaneously apply phonocardiography together with ECG and carotid plethysmography to determine cardiac systolic time intervals in parabolic flight during gravity transitions.
Secondary objective of the experiment is to simultaneously measure key variables of the central circulation during gravity transitions to expand the understanding of cardiovascular regulation in weightlessness. Furthermore spirometric measurements shall be performed during a parabolic flight day to observe changes in end-expiratory CO2. Arterial CO2 content is central for cardiovascular regulation.
Our main hypothesis is that there is no difference between different methods of central arteria pressure determination.
Concerning our secondary objective, this experiment is designed as an observational study. Thus no clear hypothesis was generated but the measured cardiovascular and respiratory variables will be analysed regarding differences correlated to gravity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DETERMINATION OF BLOOD PRESSURE | Other | determination and comparison of blood pressure by/with :
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Détermination and comparison of blood pressure | Other | Rebreathings will be performed every parabola (2, 4, 6, 8, 10…). Ultrasound measurements will be performed during the remaining parabolas (1, 3, 5, 7, 9…). The procedure consists of a fixed breathing frequency of 20 breaths per minute and an exact triggered start point for the measurements. . Central blood pressure measurements, finger blood pressure measurements, impedance cardiography, carotid plethysmography and phonocardiography will be performed continuously during the flights. The breaks between parabolas 10 and 11 and 20 and 21 will be used to change subjects, which takes approximately 5 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| Central arterial pressure | Central arterial pressure evaluated by oscillographic upper arm measurements | baseline and when in gravity (same day) |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic time intervals | Systolic time intervals evaluated in upright subjects regarding g-load. | baseline and when in gravity (same day) |
| inert gas rebreathing | Cardiac output by inert gas rebreathing |
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Inclusion Criteria:
Subjects will be staff member of the team or of other teams participating in the parabolic flight campaign
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pierre DP Denise, PhD | Contact | 02.31.06.81.32 | +33 | pierre.denise@unicaen.fr |
| Cathy GC Gaillard | Contact | 02 31 06 53 49 | +33 | gaillard-c@chu-caen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Pierre DP Denise, PhD | University Hospital, Caen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Caen CHU | Recruiting | Caen | 14000 | France |
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| baseline and when in gravity (same day) |
| heart rate | baseline and when in gravity (same day) |
| peripheral blood pressure | baseline and when in gravity (same day) |
| different methods of pulse curve analysis | Cardiac output by different methods of pulse curve analysis will be evaluated for different g-loads. | baseline and when in gravity (same day) |