This prospective cohort study is designed to observe of the effect of intervention therapy on the long-term prognosis of children with bronchiectasis. The main purpose of the study was to evaluate the degree of deterioration of lung function, to observe and compare the quality of life, the time of pulmonary exacerbation, and the changes of lung image.

All enrolled patients are followed up for half a year, 1 years, 2 years, 3 years, 4 years, 5 years, while observation of pulmonary function, symptoms, signs, quality of life, the times of acute pulmonary exacerbation, and the changes of lung image are performed.

Inclusion Criteria:A included patient must be coincident at least one point of the four items of high-resolution computed tomography (HRCT) manifestations.

• Internal bronchial diameter greater than the accompanying pulmonary artery.
• lack of bronchial tapering
• bronchi visible in the peripheral 1cm of lung
• bronchial diameter greater than adjacent segmental bronchi

Exclusion Criteria:Subject will be excluded if she or he has one of the following

• It is unable or doesn't agree to accept the follow-up process
• undergoing trial for other medications or instruments.

Children who was confirmed diagnosis as bronchiectasis at the certain hospitals (sponsor and collaborators)