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Radiofrequency catheter ablation is effective in the treatment of patients with paroxysmal atrial fibrillation. In order to reduce the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3D atrial computer model. The investigators will conduct virtual rotor mapping in the patient specific atrial model. Then, the investigators will compare the clinical outcome of conventional circumferential pulmonary vein isolation and additional rotor ablation guided by virtual rotor mapping.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| conventional group | Active Comparator | Group operating the atrial fibrillation by physician's personal experience, not by virtual simulation. |
|
| 3D atrial computer model | Experimental | Group choosing choose the best effective rotor mapping by simulating 3D atrial computer model which consider patinet's heart size and shape. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| physician's personal experience | Procedure | physician's personal experience |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Recurrence rate of atrial fibrillation of 18 months after procedure within 18 months | 18 months | |
| Rate of mortality, incidence of cerebral infarction and hospitalization after procedure | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Major complication related procedure : Complication of hemorrhagic and embolic | 24 months | |
| Pericardial effusion required treatment, 4g/dL reduced level of Hb, Hemorrhage required blood transfusion and Cerebral infarction related procedure | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hui-Nam Pak | Contact | 82-2-2228-8459 | hnpak@yuhs.ac |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Cardiovascular Hospital, Yonsei University Health System | Recruiting | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35927040 | Derived | Choi Y, Lim B, Yang SY, Yang SH, Kwon OS, Kim D, Kim YG, Park JW, Yu HT, Kim TH, Yang PS, Uhm JS, Shim J, Kim SH, Sung JH, Choi JI, Joung B, Lee MH, Kim YH, Oh YS, Pak HN; CUVIA-REGAB Investigators. Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study. Korean Circ J. 2022 Sep;52(9):699-711. doi: 10.4070/kcj.2022.0113. Epub 2022 Jul 11. |
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| Virtual rotor mapping |
| Procedure |
Virtual rotor mapping |
|
| Procedure time and Radiofrequency ablation time | 24 months |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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