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Radiofrequency catheter ablation is highly effective in the treatment of patients with persistent atrial fibrillation. In order to decrease the recurrence rate after catheter ablation, the investigators propose to apply 'virtual' ablation on patient-specific atria by simulating 3D atrial computer model. The investigators will test with five different set of ablation methods and find successful methods for a specific patient. Then, this result will be compared to empirical catheter ablation result by randomly controlled trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| virtual simulation | Experimental | This intervention group is to choose the best effective method operation to patients by simulating 3D atrial computer model which consider patient's heart size and shape. |
|
| conventional ablation | Active Comparator | The other intervention group is to operate the atrial fibrillation by physician's personal experience, not by virtual simulation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Virtual ablation in based 3D CT of patient who diagnosed AF | Procedure |
| ||
| conventional ablation based on physician's personal experience |
| Measure | Description | Time Frame |
|---|---|---|
| change of hospitalization rate | 1, 3, 6, 12, 18 and 24 months after catheter ablation and every 6 months thereafter. |
| Measure | Description | Time Frame |
|---|---|---|
| occurence of cardiovascular disease | 6 months | |
| recurrence of AF | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Hospital | Seoul | 120-752 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31920716 | Derived | Kim IS, Lim B, Shim J, Hwang M, Yu HT, Kim TH, Uhm JS, Kim SH, Joung B, On YK, Oh S, Oh YS, Nam GB, Lee MH, Shim EB, Kim YH, Pak HN; CUVIA-AF1 Investigators. Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study. Front Physiol. 2019 Dec 17;10:1512. doi: 10.3389/fphys.2019.01512. eCollection 2019. |
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| Procedure |
|
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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