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The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Obese | Experimental | Women, aged 21-45 with BMI >30 |
|
| Normal weight | Experimental | Women, aged 21-45 with BMI < 25 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endometrial fluid aspiration | Procedure | Patient will undergo a biopsy to aspirate endometrial fluid from the uterine cavity |
|
| Measure | Description | Time Frame |
|---|---|---|
| Gene expression profile in human embryos | We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls. | Samples will be collected within 1 month of enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | 94304 | United States |
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