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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-005642-22 | EudraCT Number |
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| Name | Class |
|---|---|
| University of California, San Diego | OTHER |
| Bispebjerg Hospital | OTHER |
| Smiths Medical, ASD, Inc. | INDUSTRY |
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The investigators believe sufficient spread to all nerves within the adductor canal-and thereby sufficient analgesia-can only be obtained by bolus injections and not by continuous infusions via a catheter. The aim of the study is to investigate whether an adductor canal block performed as repeated intermittent boluses provides superior pain relief to continuous infusion. The investigators hypothesize that adductor canal block performed as intermittent boluses via a catheter will reduce morphine consumption and pain as well as enhance ambulation and muscle strength compared with continuous infusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intermittent bolus | Experimental | ropivacaine 0.2%, 21 ml every 3 hours |
|
| Continuous infusion | Active Comparator | ropivacaine 0.2%, 7ml/h |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ropivacaine 0.2% | Drug | Adductor canal block. Placed immediately postoperative. Intervention stops on POD2 12PM |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total opioid consumption | Difference in total opioid consumption (patient controlled analgesia pump and any potential rescue administration) between groups, from end of surgery until 12 pm on postoperative day (POD) 2. | 2 days postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Pains scores during knee flexion as assessed by the Visual analogue scale (VAS) | Visual analogue scale (VAS) pain scores (0-100 mm) during 45 degrees active knee flexion analyzed using a linear mixed model with the inclusion of all time points (Day of surgery (DOS): 8 pm, POD 1: 8 am, 12 pm, 8 pm, POD 2: 8 am and 12 pm). | 2 days postoepratively |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesia-Surgery-Intensive Care, Gentofte Hospital | Gentofte Municipality | Hellerup | 2900 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29293181 | Derived | Jaeger P, Baggesgaard J, Sorensen JK, Ilfeld BM, Gottschau B, Graungaard B, Dahl JB, Odgaard A, Grevstad U. Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial. Anesth Analg. 2018 Jun;126(6):2069-2077. doi: 10.1213/ANE.0000000000002747. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| Pain at rest as assessed by the VAS pain scores | VAS pain scores (0-100 mm) at rest analyzed using a linear mixed model with the inclusion of all time points (DOS: 8 pm, POD 1: 8 am, 12 pm, 8 pm, POD 2: 8 am and 12 pm). | 2 days postoperatively |
| Pain during the Timed Up and Go test as assessed by the VAS | Worst pain (VAS, 0-100 mm) during the Timed Up and Go test at 12 pm on POD 1 and 2. | 1 and 2 days postoperatively |
| Quadriceps strength assessed as maximum voluntary isometric contraction in percentage of preoperative baseline values at 12 pm on POD 1 and 2 | Quadriceps strength assessed as maximum voluntary isometric contraction in percentage of preoperative baseline values at 12 pm on POD 1 and 2. | 1 and 2 days postoperatively |
| Timed Up and Go test | Time (seconds) to perform the Timed Up and Go test at 12 pm on POD 1 and 2. | 1 and 2 days postoperatively |
| Number of patients able to perform the Timed Up and Go test | Number of patients able to perform the Timed Up and Go test at 12 pm on POD 1 and 2. | 1 and 2 days postoperatively |
| 6 min walk test | Distance ambulated (m) during the 6 min walk test performed at 12 pm on POD 1 and 2. | 1 and 2 days postoperativley |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |