Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to compare the efficiency of nebulization and positive expiratory pressure combination
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nebulization combined to positive expiratory pressure | Experimental | Experimental arm |
|
| Nebulization | Active Comparator | Control arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Positive expiratory pressure | Device |
| ||
| amikacine nebulization |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary excretion of amikacin | Pharmacokinetic study of the urinary excretion of amikacin after nebulization | 24 hours after the nebulization |
| Measure | Description | Time Frame |
|---|---|---|
| breathing pattern | recoding of frequency and tidal volume during the nebulization | participants will be recorded for the duration of the nebulization, an expected average of 15 minutes |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques universitaires Saint-Luc | Recruiting | Brussels | 1200 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40199650 | Derived | Aubriot AS, Leal T, Dubus JC, Gohy S, Reychler G. Impact of adding positive expiratory pressure to nebulisation on drug delivery: a comparative study. Physiotherapy. 2026 Jun;131:101772. doi: 10.1016/j.physio.2025.101772. Epub 2025 Feb 13. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D011175 | Positive-Pressure Respiration |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Drug |
|
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |